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Browse Items (140 total)
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Creator: Iversen, Patrick L., Christopher D. Kane, Xiankun Zeng, Rekha G. Panchal, Travis K. Warren, Sheli R. Radoshitzky, Jens H. Kuhn, Rajini R. Mudhasani, Christopher L. Cooper, Amy C. Shurtleff, Farooq Nasar, Melek M. E. Sunay, Allen J. Duplantier, Brett…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-06-18
Description: The PALM trial in the Democratic Republic of the Congo identified a statistically significant survival benefit for two monoclonal antibody-based therapeutics in the treatment of acute Ebola virus disease; however, substantial gaps remain in improving… -
Creator: McElroy, Anita K., Rama S. Akondy, David R. McLlwain, Han Chen, Zach Bjornson-Hooper, Nilanjan Mukherjee, Aneesh K. Mehta, Garry Nolan, Stuart T. Nichol, and Christina F. Spiropoulou.
Subject: Research
Item Type: Publication
Date Last Updated: 2020-05-21
Description: A complete understanding of human immune responses to Ebola virus infection is limited by the availability of specimens and the requirement for biosafety level 4 (BSL-4) containment. -
Creator: Tapia, Milagritos D., Samba O. Sow, Khardiata D. Mbaye, Aliou Thiongane, Birahim P. Ndiaye, Cheikh T. Ndour, Souleymane Mboup, Babajide Keshinro, Thompson N. Kinge, Guy Vernet, Jean Joel Bigna, Stephen Oguche, Kwadwo A. Koram, Kwaku P. Asante,…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-03-19
Description: During the large 2013–16 Ebola virus outbreak caused by the Zaire Ebola virus, about 20% of cases were reported in children. This study is the first, to our knowledge, to evaluate an Ebola vaccine in children younger than 6 years. -
Creator: Tapia, Milagritos D., Samba O. Sow, Birahim P. Ndiaye, Khardiata D. Mbaye, Aliou Thiongane, Cheikh T. Ndour, Souleymane Mboup, Julie A. Ake, Babajide Keshinro, Gideon A. Akintunde, Thompson N. Kinge, Guy Vernet, Jean Joel Bigna, Stephen Oguche,…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-03-19
Description: The 2014 Zaire Ebola virus disease epidemic accelerated vaccine development for the virus. -
Creator: Bavari, Sina, and Patrick L. Iversen.
Subject: Research
Item Type: Publication
Date Last Updated: 2020-03-19
Description: Two phase 2 randomised clinical trials evaluating ChAd3-EBO-Z administered to healthy adults in Cameroon, Mali, Nigeria, and Senegal and healthy children in Mali and Senegal are reported by Milagritos Tapia and colleagues in The Lancet Infectious… -
Creator: Dean, Christina L., Jay W. Hooper, John M. Dye, Samantha E. Zak, Scott A. Koepsell, Laurence Corash, Richard J. Benjamin, Steve Kwilas, Shannon Bonds, Anne M. Winkler, and Colleen S. Kraft.
Subject: Research
Item Type: Publication
Date Last Updated: 2020-03-04
Description: In 2014, passive immunization by transfusion of Ebola convalescent plasma (ECP) was considered for treating patients with acute Ebola virus disease (EVD). -
Creator: Reisler, R. B., C. S. Kraft, S. Bavari, and A. P. Cardile
Subject: Research
Item Type: Publication
Date Last Updated: 2018-04-17
Description: "To the Editor—We read with interest the recent article in Clinical Infectious Diseases by Lanini et al, which focused on the relationship between human Ebola virus (EBOV) RNA and clinical chemistry values obtained during the West African outbreak in… -
Creator: McElroy, A. K., P. Shrivastava-Ranjan, J. R. Harmon, R. B. Martines, L. Silva-Flannery, T. D. Flietstra, C. S. Kraft, A. K. Mehta, G. M. Lyon, J. B. Varkey, B. S. Ribner, S. T. Nichol, S. R. Zaki, and C. F. Spiropoulou
Subject: Research
Item Type: Publication
Date Last Updated: 2019-02
Description: Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome… -
Creator: Kuhn, J. H., T. Adachi, N. K. J. Adhikari, J. R. Arribas, I. E. Bah, D. G. Bausch, N. Bhadelia, M. Borchert, A. B. Brantsaeter, D. M. Brett-Major, T. H. Burgess, D. S. Chertow, C. G. Chute, T. J. Cieslak, R. Colebunders, I. Crozier, R. T. Davey, H.…
Subject: Research
Item Type: Publication
Description: The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a… -
Creator: Cnops, L., J. van Griensven, A. N. Honko, D. G. Bausch, A. Sprecher, C. E. Hill, R. Colebunders, J. C. Johnson, A. Griffiths, G. F. Palacios, C. S. Kraft, G. Kobinger, A. Hewlett, D. A. Norwood, P. Sabeti, P. B. Jahrling, P. Formenty, J. H. Kuhn, and…
Subject: Research
Item Type: Publication
Date Last Updated: 2016-07
Description: Quantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and infectivity. Copyright © 2016 Elsevier Ltd. All rights reserved.