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Browse Items (139 total)

  • Tags: Therapeutics

Creator: Schafer, Adam, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E. Ramirez, Norton P. Peet, Michael Caffrey, Gregory R. J. Thatcher, Erica Ollmann Saphire, Han Cheng, and Lijun Rong.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-04
Description: Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that…

Creator: Gupta, Aakriti, Mahesh V. Madhavan, Timothy J. Poterucha, Ersilia M. DeFilippis, Jessica A. Hennessey, Bjorn Redfors, Christina Eckhardt, Behnood Bikdeli, Jonathan Platt, Ani Nalbandian, Pierre Elias, Matthew J. Cummings, Shayan N. Nouri, Matthew…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-26
Description: The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have…

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Creator: Joyner, Michael J., Rickey E. Carter, Jonathon W. Senefeld, Stephen A. Klassen, John R. Mills, Patrick W. Johnson, Elitza S. Theel, Chad C. Wiggins, Katelyn A. Bruno, Allan M. Klompas, Elizabeth R. Lesser, Katie L. Kunze, Matthew A. Sexton, Juan C.…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-03-18
Description: Convalescent plasma has been widely used to treat coronavirus disease 2019 (Covid-19) under the presumption that such plasma contains potentially therapeutic antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be…

Creator: Garibaldi, Brian T., Kunbo Wang, Matthew L. Robinson, Scott L. Zeger, Karen Bandeen-Roche, Mei-Cheng Wang, G. Caleb Alexander, Amita Gupta, Robert Bollinger, and Yanxun Xu.
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-03-01
Description: Clinical effectiveness data on remdesivir are urgently needed, especially among diverse populations and in combination with other therapies.

Creator: Liu, Yang, Jianying Liu, Hongjie Xia, Xianwen Zhang, Camila R. Fontes-Garfias, Kena A. Swanson, Hui Cai, Ritu Sarkar, Wei Chen, Mark Cutler, David Cooper, Scott C. Weaver, Alexander Muik, Ugur Sahin, Kathrin U. Jansen, Xuping Xie, Philip R.…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-03-08
Description: BNT162b2 is a nucleoside-modified RNA vaccine expressing the full-length prefusion spike glycoprotein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In a randomized, placebo-controlled clinical trial involving approximately…

Creator: PRINCIPLE Trial Collaborative Group
Subject: Research
Item Type: Publication
Date Last Updated: 2021-03-04
Description: Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community randomised trials is lacking. We aimed to assess the effectiveness of azithromycin to treat suspected…

Creator: The RECOVERY Collaborative Group.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-25
Description: Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death.

Creator: The REMAP-CAP Investigators
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-25
Description: The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.

Creator: the PlasmAr Study Group
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-18
Description: Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available from adequately powered randomized, controlled…

Creator: the Fundación INFANT–COVID-19 Group
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-18
Description: Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier…