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Browse Items (148 total)

  • Tags: Therapeutics

Creator: the ACTT-3 study group
Subject: Research
Item Type: Publication
Date Last Updated: 2021-10-18
Description: Functional impairment of interferon, a natural antiviral component of the immune system, is associated with the pathogenesis and severity of COVID-19. We aimed to compare the efficacy of interferon beta-1a in combination with remdesivir compared with…

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Creator: NETEC
Subject: Treatment & Care
Item Type: Webinar
Date Last Updated: 2021-11-05
Description: Join us Friday, November 5th, at 1 pm EST for a NETEC COVID-19 Webinar Series presentation, Monoclonal Antibody Therapy in Residential Healthcare Settings. Topics will include the role monoclonal antibody (mAb) therapy is playing in treating COVID-19…

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Creator: the BLAZE-1 Investigators
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-10-07
Description: Patients with underlying medical conditions are at increased risk for severe coronavirus disease 2019 (Covid-19). Whereas vaccine-derived immunity develops over time, neutralizing monoclonal-antibody treatment provides immediate, passive immunity and…

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Creator: Barbaro, Ryan P., Graeme MacLaren, Philip S. Boonstra, Alain Combes, Cara Agerstrand, Gail Annich, Rodrigo Diaz, Eddy Fan, Katarzyna Hryniewicz, Roberto Lorusso, Matthew L. Paden, Christine M. Stead, Justyna Swol, Theodore J. Iwashyna, Arthur S.…
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-09-29
Description: Over the course of the COVID-19 pandemic, the care of patients with COVID-19 has changed and the use of extracorporeal membrane oxygenation (ECMO) has increased. We aimed to examine patient selection, treatments, outcomes, and ECMO centre…

Creator: Fintzi J, Bonnett T, Sweeney DA, Huprikar NA, Ganesan A, Frank MG, McLellan SLF, Dodd LE, Tebas P, Mehta AK.
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-08-19
Description: The Adaptive COVID-19 Treatment Trial-1 (ACTT-1) found that remdesivir therapy hastened recovery in patients hospitalized with COVID-19, but the pathway for this improvement was not explored. We investigated how the dynamics of clinical progression…

Creator: Bourguignon, Alex, Donald M. Arnold, Theodore E. Warkentin, James W. Smith, Tania Pannu, Jeffrey M. Shrum, Zainab A. A. Al Maqrashi, Anjali Shroff, Marie-Claude Lessard, Normand Blais, John G. Kelton, and Ishac Nazy.
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-08-19
Description: The use of high-dose intravenous immune globulin (IVIG) plus anticoagulation is recommended for the treatment of vaccine-induced immune thrombotic thrombocytopenia (VITT), a rare side effect of adenoviral vector vaccines against coronavirus disease…

Creator: the Overcoming COVID-19 Investigators
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-06-16
Description: The assessment of real-world effectiveness of immunomodulatory medications for multisystem inflammatory syndrome in children (MIS-C) may guide therapy.

Creator: The RECOVERY Collaborative Group
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-05-14
Description: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.A response to this article was…

Creator: Rosas, Ivan O., Norbert Bräu, Michael Waters, Ronaldo C. Go, Bradley D. Hunter, Sanjay Bhagani, Daniel Skiest, Mariam S. Aziz, Nichola Cooper, Ivor S. Douglas, Sinisa Savic, Taryn Youngstein, Lorenzo Del Sorbo, Antonio Cubillo Gracian, David J. De…
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-04-22
Description: Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better…

Creator: Schafer, Adam, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E. Ramirez, Norton P. Peet, Michael Caffrey, Gregory R. J. Thatcher, Erica Ollmann Saphire, Han Cheng, and Lijun Rong.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-04
Description: Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that…