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Browse Items (103 total)
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- Creator:
- Schafer, Adam, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E. Ramirez, Norton P. Peet, Michael Caffrey, Gregory R. J. Thatcher, Erica Ollmann Saphire, Han Cheng, and Lijun Rong.
- Subject:
- Research
- Item Type:
- Publication
- Date Last Updated:
- 2021-02-04
- Description:
- Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that…
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- Creator:
- Strampe, Jamie, Danny A. Asogun, Emily Speranza, Meike Pahlmann, Ali Soucy, Sabrina Bockholt, Elisa Pallasch, Beate Becker-Ziaja, Sophie Duraffour, Nahid Bhadelia, Yemisi Ighodalo, Jennifer Oyakhilome, Emmanuel O. Omomoh, Thomas Olokor, Donatus I.…
- Subject:
- Research
- Item Type:
- Publication
- Date Last Updated:
- 2021-01-20
- Description:
- Lassa fever is endemic in several west African countries. Case-fatality rates ranging from 21% to 69% have been reported. The pathophysiology of the disease in humans and determinants of mortality remain poorly understood. We aimed to determine host…
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- Creator:
- Blair, P. W., M. G. Kortepeter, L. G. Downey, C. S. Madar, I. L. Downs, K. A. Martins, F. Rossi, J. A. Williams, A. Madar, C. W. Schellhase, J. J. Bearss, X. Zeng, S. Bavari, V. Soloveva, J. B. Wells, K. S. Stuthman, N. L. Garza, S. A. Vantongeren,…
- Subject:
- Research
- Item Type:
- Publication
- Date Last Updated:
- 2020-12-25
- Description:
- Ebola virus disease (EVD) supportive care strategies are largely guided by retrospective observational research. This study investigated the effect of EVD supportive care algorithms on duration of survival in a controlled nonhuman primate (NHP)…
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- Creator:
- Thom, Ruth, Thomas Tipton, Thomas Strecker, Yper Hall, Joseph Akoi Bore, Piet Maes, Fara Raymond Koundouno, Sarah Katharina Fehling, Verena Krähling, Kimberley Steeds, Anitha Varghese, Graham Bailey, Mary Matheson, Moussa Coné, Balla Moussa Keita,…
- Subject:
- Research
- Item Type:
- Publication
- Date Last Updated:
- 2020-10-13
- Description:
- The 2013–16 Ebola virus disease epidemic in west Africa caused international alarm due to its rapid and extensive spread resulting in a significant death toll and social unrest within the affected region. The large number of cases provided an…
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- Creator:
- the Medical Countermeasures Working Group of the National Ebola Training and Education Center’s (NETEC’s) Special Pathogens Research Network (SPRN)
- Subject:
- Research
- Item Type:
- Publication
- Date Last Updated:
- 2020-08-03
- Description:
- This article is a summary of countermeasures for Marburg virus disease focusing on pathogenesis, clinical features, and diagnostics, with an emphasis on therapies and vaccines that have demonstrated potential for use in an emergency situation,…
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- Creator:
- Iversen, Patrick L., Christopher D. Kane, Xiankun Zeng, Rekha G. Panchal, Travis K. Warren, Sheli R. Radoshitzky, Jens H. Kuhn, Rajini R. Mudhasani, Christopher L. Cooper, Amy C. Shurtleff, Farooq Nasar, Melek M. E. Sunay, Allen J. Duplantier, Brett…
- Subject:
- Research
- Item Type:
- Publication
- Date Last Updated:
- 2020-06-18
- Description:
- The PALM trial in the Democratic Republic of the Congo identified a statistically significant survival benefit for two monoclonal antibody-based therapeutics in the treatment of acute Ebola virus disease; however, substantial gaps remain in improving…
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- Creator:
- McElroy, Anita K., Rama S. Akondy, David R. McLlwain, Han Chen, Zach Bjornson-Hooper, Nilanjan Mukherjee, Aneesh K. Mehta, Garry Nolan, Stuart T. Nichol, and Christina F. Spiropoulou.
- Subject:
- Research
- Item Type:
- Publication
- Date Last Updated:
- 2020-05-21
- Description:
- A complete understanding of human immune responses to Ebola virus infection is limited by the availability of specimens and the requirement for biosafety level 4 (BSL-4) containment.
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- Creator:
- Tapia, Milagritos D., Samba O. Sow, Khardiata D. Mbaye, Aliou Thiongane, Birahim P. Ndiaye, Cheikh T. Ndour, Souleymane Mboup, Babajide Keshinro, Thompson N. Kinge, Guy Vernet, Jean Joel Bigna, Stephen Oguche, Kwadwo A. Koram, Kwaku P. Asante,…
- Subject:
- Research
- Item Type:
- Publication
- Date Last Updated:
- 2020-03-19
- Description:
- During the large 2013–16 Ebola virus outbreak caused by the Zaire Ebola virus, about 20% of cases were reported in children. This study is the first, to our knowledge, to evaluate an Ebola vaccine in children younger than 6 years.
