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Browse Items (73 total)
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Creator: the ACTT-1 Study Group Members
Subject: Research
Item Type: Publication
Date Last Updated: 2020-11-05
Description: We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.A response to this article was published:Dolin, Raphael,… -
Creator: Ng, Oon Tek, Kalisvar Marimuthu, Vanessa Koh, Junxiong Pang, Kyaw Zaw Linn, Jie Sun, Liang De Wang, Wan Ni Chia, Charles Tiu, Monica Chan, Li Min Ling, Shawn Vasoo, Mohammad Yazid Abdad, Po Ying Chia, Tau Hong Lee, Ray Junhao Lin, Sapna P.…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-11-02
Description: The proportion of asymptomatic carriers and transmission risk factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among household and non-household contacts remains unclear. -
Creator: Ward, Brian J., Alexander Makarkov, Annie Séguin, Stéphane Pillet, Sonia Trépanier, Jiwanjeet Dhaliwall, Michael D. Libman, Timo Vesikari, and Nathalie Landry.
Subject: Laboratory
Item Type: Publication
Date Last Updated: 2020-10-13
Description: Seasonal influenza remains a substantial public health threat despite the availability of egg-derived and other vaccines. Plant-based manufacturing might address some of the limitations of current vaccines. We describe two phase 3 efficacy studies of… -
Creator: Poland, Gregory A., Inna G. Ovsyannikova, and Richard B. Kennedy.
Subject: Laboratory
Item Type: Publication
Date Last Updated: 2020-10-13
Description: Understanding immune responses to severe acute respiratory syndrome coronavirus 2 is crucial to understanding disease pathogenesis and the usefulness of bridge therapies, such as hyperimmune globulin and convalescent human plasma, and to developing… -
Creator: Thom, Ruth, Thomas Tipton, Thomas Strecker, Yper Hall, Joseph Akoi Bore, Piet Maes, Fara Raymond Koundouno, Sarah Katharina Fehling, Verena Krähling, Kimberley Steeds, Anitha Varghese, Graham Bailey, Mary Matheson, Moussa Coné, Balla Moussa Keita,…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-10-13
Description: The 2013–16 Ebola virus disease epidemic in west Africa caused international alarm due to its rapid and extensive spread resulting in a significant death toll and social unrest within the affected region. The large number of cases provided an… -
Creator: Mok, Chris Ka Pun, Airu Zhu, Jingxian Zhao, Eric H. Y. Lau, Junxiang Wang, Zhao Chen, Zhen Zhuang, Yanqun Wang, Abeer N. Alshukairi, Salim A. Baharoon, Wenling Wang, Wenjie Tan, Weiwen Liang, Jamiu O. Oladipo, Ranawaka A. P. M. Perera, Sulyman A.…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-10-06
Description: Middle East respiratory syndrome (MERS) remains of global public health concern. Dromedary camels are the source of zoonotic infection. Over 70% of MERS coronavirus (MERS-CoV)-infected dromedaries are found in Africa but no zoonotic disease has been… -
Creator: Horby, Peter W., Marion Mafham, Jennifer L. Bell, Louise Linsell, Natalie Staplin, Jonathan Emberson, Adrian Palfreeman, Jason Raw, Einas Elmahi, Benjamin Prudon, Christopher Green, Simon Carley, David Chadwick, Matthew Davies, Matthew P. Wise, J.…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-10-05
Description: Lopinavir–ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity, preclinical studies, and observational studies. Here, we report the results of a randomised trial to assess whether lopinavir–ritonavir improves… -
Creator: Wyllie, Anne L., John Fournier, Arnau Casanovas-Massana, Melissa Campbell, Maria Tokuyama, Pavithra Vijayakumar, Joshua L. Warren, Bertie Geng, M. Catherine Muenker, Adam J. Moore, Chantal B. F. Vogels, Mary E. Petrone, Isabel M. Ott, Peiwen Lu,…
Subject: Laboratory
Item Type: Publication
Date Last Updated: 2020-09-24
Description: Rapid and accurate diagnostic tests are essential for controlling the ongoing Covid-19 pandemic. Although the current standard involves testing of nasopharyngeal swab specimens by quantitative reverse-transcriptase polymerase chain reaction (RT-qPCR)… -
Creator: Garibaldi, B. T., J. Fiksel, J. Muschelli, M. L. Robinson, M. Rouhizadeh, J. Perin, G. Schumock, P. Nagy, J. H. Gray, H. Malapati, M. Ghobadi-Krueger, T. M. Niessen, B. S. Kim, P. M. Hill, M. S. Ahmed, E. D. Dobkin, R. Blanding, J. Abele, B. Woods,…
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2020-09-22
Description: Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts. -
Creator: Logunov, Denis Y., Inna V. Dolzhikova, Olga V. Zubkova, Amir I. Tukhvatullin, Dmitry V. Shcheblyakov, Alina S. Dzharullaeva, Daria M. Grousova, Alina S. Erokhova, Anna V. Kovyrshina, Andrei G. Botikov, Fatima M. Izhaeva, Olga Popova, Tatiana A.…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-09-21
Description: We developed a heterologous COVID-19 vaccine consisting of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector, both carrying the gene for severe acute respiratory syndrome coronavirus 2…