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Browse Items (73 total)
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Creator: the ACTT-1 Study Group Members
Subject: Research
Item Type: Publication
Date Last Updated: 2020-11-05
Description: We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.A response to this article was published:Dolin, Raphael,… -
Creator: Strampe, Jamie, Danny A. Asogun, Emily Speranza, Meike Pahlmann, Ali Soucy, Sabrina Bockholt, Elisa Pallasch, Beate Becker-Ziaja, Sophie Duraffour, Nahid Bhadelia, Yemisi Ighodalo, Jennifer Oyakhilome, Emmanuel O. Omomoh, Thomas Olokor, Donatus I.…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-01-20
Description: Lassa fever is endemic in several west African countries. Case-fatality rates ranging from 21% to 69% have been reported. The pathophysiology of the disease in humans and determinants of mortality remain poorly understood. We aimed to determine host… -
Creator: Stone, John H., Matthew J. Frigault, Naomi J. Serling-Boyd, Ana D. Fernandes, Liam Harvey, Andrea S. Foulkes, Nora K. Horick, Brian C. Healy, Ruta Shah, Ana Maria Bensaci, Ann E. Woolley, Sarah Nikiforow, Nina Lin, Manish Sagar, Harry Schrager, David…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-10-21
Description: The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. -
Creator: Shaw, Robert H., Arabella Stuart, Melanie Greenland, Xinxue Liu, Jonathan S. Nguyen Van-Tam, and Matthew D. Snape.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-05-12
Description: There is significant international interest in heterologous prime-boost COVID-19 vaccination to mitigate against supply shocks or shortages that might otherwise reduce the speed of vaccine roll-out. Additionally, in light of changing recommendations… -
Creator: Scully, Marie, Deepak Singh, Robert Lown, Anthony Poles, Tom Solomon, Marcel Levi, David Goldblatt, Pavel Kotoucek, William Thomas, and William Lester.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-16
Description: The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a year, several vaccines have been developed and millions of doses delivered.… -
Creator: Schultz, Nina H., Ingvild H. Sørvoll, Annika E. Michelsen, Ludvig A. Munthe, Fridtjof Lund-Johansen, Maria T. Ahlen, Markus Wiedmann, Anne-Hege Aamodt, Thor H. Skattør, Geir E. Tjønnfjord, and Pål A. Holme.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-09
Description: We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). -
Creator: Rubino, Francesco, Stephanie A. Amiel, Paul Zimmet, George Alberti, Stefan Bornstein, Robert H. Eckel, Geltrude Mingrone, Bernhard Boehm, Mark E. Cooper, Zhonglin Chai, Stefano Del Prato, Linong Ji, David Hopkins, William H. Herman, Kamlesh Khunti,…
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2020-08-20
Description: There is a bidirectional relationship between Covid-19 and diabetes. On the one hand, diabetes is associated with an increased risk of severe Covid-19. On the other hand, new-onset diabetes and severe metabolic complications of preexisting diabetes,… -
Creator: Ruan, Shigui.
Subject: Research
Item Type: Publication
Date Last Updated: 2020-03-30
Description: A case fatality ratio of an infectious disease measures the proportion of all individuals diagnosed with a disease who will die from that disease. -
Creator: Rosas, Ivan O., Norbert Bräu, Michael Waters, Ronaldo C. Go, Bradley D. Hunter, Sanjay Bhagani, Daniel Skiest, Mariam S. Aziz, Nichola Cooper, Ivor S. Douglas, Sinisa Savic, Taryn Youngstein, Lorenzo Del Sorbo, Antonio Cubillo Gracian, David J. De La…
Subject: Treatment & Care
Item Type: Publication
Date Last Updated: 2021-04-22
Description: Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better… -
Creator: Puelles, Victor G., Marc Lütgehetmann, Maja T. Lindenmeyer, Jan P. Sperhake, Milagros N. Wong, Lena Allweiss, Silvia Chilla, Axel Heinemann, Nicola Wanner, Shuya Liu, Fabian Braun, Shun Lu, Susanne Pfefferle, Ann S. Schröder, Carolin Edler, Oliver…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-08-06
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) preferentially infects cells in the respiratory tract, but its direct affinity for organs other than the lungs remains poorly defined. Here, we present data from an autopsy series of 27…