Multiorgan and Renal Tropism of SARS-CoV-2

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Title

Multiorgan and Renal Tropism of SARS-CoV-2

Subject

Description

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) preferentially infects cells in the respiratory tract, but its direct affinity for organs other than the lungs remains poorly defined. Here, we present data from an autopsy series of 27 patients (see the clinical data in Table S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org) that show that SARS-CoV-2 can be detected in multiple organs, including the lungs, pharynx, heart, liver, brain, and kidneys.

Date Last Updated (Year-Month-Day)

2020-08-06

Citation

Puelles, Victor G., Marc Lütgehetmann, Maja T. Lindenmeyer, Jan P. Sperhake, Milagros N. Wong, Lena Allweiss, Silvia Chilla, Axel Heinemann, Nicola Wanner, Shuya Liu, Fabian Braun, Shun Lu, Susanne Pfefferle, Ann S. Schröder, Carolin Edler, Oliver Gross, Markus Glatzel, Dominic Wichmann, Thorsten Wiech, Stefan Kluge, Klaus Pueschel, Martin Aepfelbacher, and Tobias B. Huber. 2020. "Multiorgan and Renal Tropism of SARS-CoV-2." New England Journal of Medicine 383 (6):590-2.

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Free online on NEJM.