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Browse Items (92 total)
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Creator: Sadoff, Jerald, Mathieu Le Gars, Georgi Shukarev, Dirk Heerwegh, Carla Truyers, Anne M. de Groot, Jeroen Stoop, Sarah Tete, Wim Van Damme, Isabel Leroux-Roels, Pieter-Jan Berghmans, Murray Kimmel, Pierre Van Damme, Jan de Hoon, William Smith, Kathryn…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-05-13
Description: Efficacious vaccines are urgently needed to contain the ongoing coronavirus disease 2019 (Covid-19) pandemic of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A candidate vaccine, Ad26.COV2.S, is a recombinant,… -
Creator: Davis, Carl W., Katherine J. L. Jackson, Megan M. McCausland, Jaime Darce, Cathy Chang, Susanne L. Linderman, Chakravarthy Chennareddy, Rebecca Gerkin, Shantoria J. Brown, Jens Wrammert, Aneesh K. Mehta, Wan Cheung Cheung, Scott D. Boyd, Edmund K.…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-08-13
Description: A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains, but also long-lasting. Because long-term serum antibody levels are maintained by bone… -
Creator: Zhu, Feng-Cai, Xu-Hua Guan, Yu-Hua Li, Jian-Ying Huang, Tao Jiang, Li-Hua Hou, Jing-Xin Li, Bei-Fang Yang, Ling Wang, Wen-Juan Wang, Shi-Po Wu, Zhao Wang, Xiao-Hong Wu, Jun-Jie Xu, Zhe Zhang, Si-Yue Jia, Bu-Sen Wang, Yi Hu, Jing-Jing Liu, Jun Zhang,…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-07-20
Description: This is the first randomised controlled trial for assessment of the immunogenicity and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose of the candidate vaccine for an… -
Creator: Shaw, Robert H., Arabella Stuart, Melanie Greenland, Xinxue Liu, Jonathan S. Nguyen Van-Tam, and Matthew D. Snape.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-05-12
Description: There is significant international interest in heterologous prime-boost COVID-19 vaccination to mitigate against supply shocks or shortages that might otherwise reduce the speed of vaccine roll-out. Additionally, in light of changing recommendations… -
Creator: Corbett, Kizzmekia S., Barbara Flynn, Kathryn E. Foulds, Joseph R. Francica, Seyhan Boyoglu-Barnum, Anne P. Werner, Britta Flach, Sarah O’Connell, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Hanne Andersen, David R. Martinez, Amy T. Noe, Naomi…
Subject: Research
Item Type: Publication
Date Last Updated: 2020-07-28
Description: Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed. The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on viral replication in both upper and lower airways is important to evaluate in nonhuman… -
Creator: Ward, Brian J., Alexander Makarkov, Annie Séguin, Stéphane Pillet, Sonia Trépanier, Jiwanjeet Dhaliwall, Michael D. Libman, Timo Vesikari, and Nathalie Landry.
Subject: Laboratory
Item Type: Publication
Date Last Updated: 2020-10-13
Description: Seasonal influenza remains a substantial public health threat despite the availability of egg-derived and other vaccines. Plant-based manufacturing might address some of the limitations of current vaccines. We describe two phase 3 efficacy studies of… -
Creator: the Oxford COVID-19 Vaccine Trial Group
Subject: Research
Item Type: Publication
Date Last Updated: 2021-03-30
Description: A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19 (AZD1222), against this variant. -
Creator: the COVE Study Group
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-04
Description: Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle–encapsulated mRNA-based vaccine that encodes the prefusion stabilized… -
Creator: Prendecki, Maria, Candice Clarke, Jonathan Brown, Alison Cox, Sarah Gleeson, Mary Guckian, Paul Randell, Alessia Dalla Pria, Liz Lightstone, Xiao-Ning Xu, Wendy Barclay, Stephen P. McAdoo, Peter Kelleher, and Michelle Willicombe.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-25
Description: The rapid implementation of SARS-CoV-2 vaccination is now a global health-care priority. Successful phase 3 trial outcomes have been reported for numerous vaccines that induce robust humoral and cellular immune responses against the SARS-CoV-2 spike… -
Creator: Bebell, Lisa M., Titilope Oduyebo, and Laura E. Riley.
Subject: Research
Item Type: Publication
Date Last Updated: 2017-03-15
Description: The 2014-2016 Ebola virus disease (EVD) outbreak in West Africa devastated local health systems and caused thousands of deaths.