Integrating Clinical Research into Epidemic Response

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Title

Integrating Clinical Research into Epidemic Response

Subject

Description

Table of Contents

 

Front Matter

i-xxvi

Summary

1-18

1 Introduction

19-36

2 Conducting Clinical Research During an Epidemic

37-82

3 Assessment of Therapeutic Trials

83-112

4 Assessment of Vaccine Trials

113-154

5 Strengthening Capacity for Response and Research

155-198

6 Engaging Communities in Research and Response

199-222

7 Facilitating International Coordination and Collaboration

223-250

Appendix A: Study Approach and Methods

251-286

Appendix B: Clinical Trial Designs

287-296

Appendix C: Ethical Principles for Research with Human Subjects

297-300

Appendix D: Biographical Sketches of Committee Members and Staff

301-316

Date Last Updated (Year-Month-Day)

2017-04-12

Citation

National Academies of Sciences, Engineering, and Medicine. 2017. Integrating Clinical Research into Epidemic Response: The Ebola Experience. Washington, DC: The National Academies Press. https://doi.org/10.17226/24739.

Abstract

Contributors

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Global Health; Board on Health Sciences Policy; Committee on Clinical Trials During the 2014-2015 Ebola Outbreak; Gerald Keusch, Keith McAdam, Patricia A. Cuff, Michelle Mancher, and Emily R. Busta, Editors

Description

The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014–2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Heath Organization declared the 2014-2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak.

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