NETEC Resource Library

Covid-19–Associated Myopathy Caused by Type I Interferonopathy


Click for External Resource*

Click to read full article*

*The link above may share a zip file (.zip) hosted on Zip files will download automatically.
*All other links are external and will open in a new window. If you click an external link, you are leaving the NETEC site, and we do not maintain, review, or endorse these materials. See our terms of use.

Item Type


Terms of Use

By accessing these materials you are agreeing to our terms of use, which may be found here: Terms of Use.

Was this resource helpful?


Covid-19–Associated Myopathy Caused by Type I Interferonopathy


The syndrome of Covid-19 infection includes myalgias and elevated creatine kinase levels in at least a third of patients. Whether the elevation in creatine kinase level is caused by viral infection of muscle, toxic effects of cytokines, or another mechanism is unclear. There are few reports of muscle-biopsy findings in patients with Covid-19. We describe a patient with Covid-19 infection and myopathy who had a muscle-biopsy specimen showing evidence of virus-induced type I interferonopathy.




Manzano, Giovanna S., Jared K. Woods, and Anthony A. Amato. 2020. "Covid-19–Associated Myopathy Caused by Type I Interferonopathy." New England Journal of Medicine.


Free online on NEJM.


Related Resource Topic Exhibits