COVID-19 and multisystem inflammatory syndrome in children and adolescents

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Title

COVID-19 and multisystem inflammatory syndrome in children and adolescents

Subject

Description

As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing reports from Europe, North America, Asia, and Latin America describing children and adolescents with COVID-19-associated multisystem inflammatory conditions.

A response to this article was published:

Date Last Updated (Year-Month-Day)

2020-08-17

Citation

Jiang, Li, Kun Tang, Mike Levin, Omar Irfan, Shaun K. Morris, Karen Wilson, Jonathan D. Klein, and Zulfiqar A. Bhutta. 2020. "COVID-19 and multisystem inflammatory syndrome in children and adolescents." The Lancet Infectious Diseases.

Abstract

Summary

As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing reports from Europe, North America, Asia, and Latin America describing children and adolescents with COVID-19-associated multisystem inflammatory conditions. However, the association between multisystem inflammatory syndrome in children and COVID-19 is still unknown. We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. We also discuss the possible underlying pathophysiological mechanisms for COVID-19-induced inflammatory processes, which can lead to organ damage in paediatric patients who are severely ill. These insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition and also shed light on future therapeutic interventions and the potential for vaccine development.

Translations

For the French, Chinese, Arabic, Spanish and Russian translations of the abstract see Supplementary Materials section.

Accessibility

Free online on Lancet site.