Clinical care of two patients with Ebola virus disease in the United States
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Título
Clinical care of two patients with Ebola virus disease in the United States
Materia
Descripción
West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history.
Fecha
2014-12-18
Tipo
Citación
Lyon, G. M., A. K. Mehta, J. B. Varkey, K. Brantly, L. Plyler, A. K. McElroy, C. S. Kraft, J. S. Towner, C. Spiropoulou, U. Stroher, T. M. Uyeki, B. S. Ribner and U. Emory Serious Communicable Diseases (2014). "Clinical care of two patients with Ebola virus disease in the United States." N Engl J Med 371(25): 2402-2409.
Resumen
West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma.
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