Pathophysiology of COVID-19

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Pathophysiology of COVID-19



This printable flyer tells you about the pathophysiology of COVID-19.

A typical presentation for COVID-19 includes cough, dyspnea, and an x-ray with diffuse opacities in the lungs. As the disease progresses, patients may develop increased respiratory failure, a hypercoagulable state, and excessive levels of pro-inflammatory and anti-infammatory cytokines similar to Macrophage Activation Syndrome (MAS). We are learning more about what is typical every day, however.

Each of these hallmark physiological states of COVID-19 result from SARS-CoV-2 infection via binding of its spike protein to the Angiotensin Converting 2 (ACE2) receptor on a variety of cell types, primarily epithelial. ACE2 normally cleaves regulatory proteins including angiotensins-2. Binding of the virus disprupts normal cellular regulation resulting in high levels of inflammation and cell death.


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