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Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

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Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Feverhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682919/pdf/nihms904566.pdf

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Title

Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

Description

Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir.

Date

2017-09-01

Citation

Raabe, V. N., G. Kann, B. S. Ribner, A. Morales, J. B. Varkey, A. K. Mehta, G. M. Lyon, S. Vanairsdale, K. Faber, S. Becker, M. Eickmann, T. Strecker, S. Brown, K. Patel, P. De Leuw, G. Schuettfort, C. Stephan, H. Rabenau, J. D. Klena, P. E. Rollin, A. McElroy, U. Stroher, S. Nichol, C. S. Kraft, T. Wolf and U. Emory Serious Communicable Diseases (2017). "Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever." Clin Infect Dis 65(5): 855-859.

Abstract

Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir. Both patients survived but developed transaminitis and had prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmission of Lassa virus should be considered.

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free online - Pubmed Central

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