NETEC Resource Library

Pathophysiology of COVID-19

Item

Files for Download

NETEC_Pathophys_Final_102020.pdfNETEC_Pathophys_Final_102020.pdf

Item Type

Guide

Terms of Use

By accessing these materials you are agreeing to our terms of use, which may be found here: Terms of Use.

Document Viewer

Was this resource helpful?


Title

Pathophysiology of COVID-19

Subject

Description

This printable flyer infographic tells you about the pathophysiology of COVID-19.

A typical presentation for COVID-19 includes cough, dyspnea, and an x-ray with diffuse opacities in the lungs. As the disease progresses, patients may develop increased respiratory failure, a hypercoagulable state, and excessive levels of pro-inflammatory and anti-inflammatory cytokines similar to Macrophage Activation Syndrome (MAS). We are learning more about what is typical every day, however.

Each of these hallmark physiological states of COVID-19 result from SARS-CoV-2 infection via binding of its spike protein to the Angiotensin Converting 2 (ACE2) receptor on a variety of cell types, primarily epithelial. ACE2 normally cleaves regulatory proteins including angiotensins-2. Binding of the virus disrupts normal cellular regulation resulting in high levels of inflammation and cell death.

Creator

Date

2020-10-20

Collection