Contents

Contributors xi

Peer Reviewers xvii

Foreword by The Surgeon General xxi

Preface xxiii

1. Historical Overview: From Poisoned Darts to Pan-Hazard Preparedness 1 George W. Christopher, Daniel M. Gerstein, Edward M. Ei en, and James W. Martin
2. Epidemiology of Biowarfare and Bioterrorism 37 Zygmunt F. Dembek, Julie A. Pavlin, Martina Siwek, and Mark G. Kortepeter
3. Food, Waterborne, and Agricultural Diseases 71 Zygmunt F. Dembek, and Edwin L. Anderson
4. Consequence Management: The Local and National Response 93 Neal E. Woollen, and Gary W. Carter
5. Medical Management of Potential Biological Casualties: A Stepwise Approach 109 Theodore J. Cieslak
6. Anthrax 129 Bret K. Purcell, Christopher K. Cote, Patricia L. Worsham, and Arthur M. Friedlander
7. Brucellosis 159 Bret K. Purcell, R. Martin Roop II, Arthur M. Friedlander, and David L. Hoover
8. Glanders 177 Susan L. Welkos, Bridget Carr Gregory, David M. Waag, and Mary N. Burtnick
9. Melioidosis 223 Paul J. Bre , David DeShazer, and Nicholas J. Vietri
10. Plague 247 Patricia L. Worsham, Thomas W. McGovern, Nicholas J. Vietri, Arthur M. Friedlander, and Joel Bozue
11. Tularemia 285 Ma hew J. Hepburn, Todd M. Kijek, Wendy Sammons-Jackson, Arthur M. Friedlander, and
    Zygmunt F. Dembek
12. Q Fever 305 Christina M. Farris and James E. Samuel
13. Multidrug-Resistant Bacterial Infections as a Threat to the US Military Health System: 321 Acinetobacter Infections as a Case Study
    Emil Lesho, Luther E. Lindler, Bruno Petruccelli, and Glenn Wortmann
14. Botulinum Toxin 337 Zygmunt F. Dembek, Leonard A. Smith, Frank J. Lebeda, and Janice M. Rusnak
15. Clostridium Perfringens Epsilon Toxin 361 Bradley G. Stiles, Gillian Barth, and Michel R. Popo
16. Ricin 373 Virginia I. Roxas-Duncan, Martha L. Hale, Jon M. Davis, John C. Gorbet, Patricia M. Legler, and
    Leonard M. Smith
17. Staphylococcal Enterotoxin B and Related Toxins Produced by Staphylococcus Aureus and 403 Streptococcus Pyogenes
    Kamal U. Saikh, Robert G. Ulrich, and Teresa Krakauer
18. Toxins from Venoms and Poisons 415 Sco A. Weinstein and Julian White
19. Marine Algal Toxins of Concern as Intentional Contaminants 461 Mark A. Poli and Mark R. Withers
20. Alphavirus Encephalitides 479 Shelley P. Honnold, Eric C. Mossel, Lesley C. Dupuy, Elaine M. Morazzani, Shannon S. Martin,
    Mary Kate Hart, George V. Ludwig, Michael D. Parker, Jonathan F. Smith, Douglas S. Reed, and
    Pamela J. Glass
21. Hemorrhagic Fever-Causing Mammarenaviruses 517 Sheli R. Radoshi ky, Jens H. Kuhn, Peter B. Jahrling, and Sina Bavari
22. Henipaviruses 547 Arnold Park, Sheli R. Radoshi ky, Jens H. Kuhn, and Benhur Lee
23. Filoviruses 569 Sheli R. Radoshi ky, Sina Bavari, Peter B. Jahrling, and Jens H. Kuhn
24. Smallpox and Related Orthopoxviruses 615 Arthur J. Go , Sara C. Johnston, Kenny L. Lin, Peter B. Jahrling, John W. Huggins, M. So Ibrahim,
    James V. Lawler, and James W. Martin
25. Emerging Infectious Diseases and Future Threats 645 Chris A. Whitehouse and Bre Bei el
26. Laboratory Identi cation of Threats 701 David A. Norwood, Timothy D. Minogue, Randal J. Schoepp, and Mark J. Wolco
27. Medical Countermeasures 751 Phillip R. Pi man, Elizabeth Brown, and Ma hew S. Chambers
28. Future Prospects of Vaccines and Antibodies in Biodefense 823 Je rey Froude II, Crystal W. Burke, and Jean-Nicolas Tournier
29. Aerobiology: History, Development, and Programs 855 Douglas S. Reed, Aysegul Nalca, and Chad J. Roy
30. Biosafety 869 David E. Harbourt, Catherine L. Wilhelmsen, Kristie M. Yeakle, and Robert J. Hawley
31. Biological Surety 895 Samuel S. Edwin, Virginia I. Roxas-Duncan, America M. Ceralde, Shelley C. Jorgensen, and Neal E. Woollen
32. Ethical Issues in the Development of Drugs and Vaccines for Biodefense 915 Arthur O. Anderson, Je rey E. Stephenson, and Bret K. Purcell