The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States
Contenu
Click for External Resource*
Click to read full article*
*The link above may share a zip file (.zip) hosted on repository.netecweb.org. Zip files will download automatically.
*All other links are external and will open in a new window. If you click an external link, you are leaving the NETEC site, and we do not maintain, review, or endorse these materials. See our terms of use.
Files for Download
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542597/pdf/civ334.pdf
Item Type
PublicationTerms of Use
By accessing these materials you are agreeing to our terms of use, which may be found here: Terms of Use.
Voir les documents
Titre
The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States
Sujet
Description
The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management.
Date
2015-08-15
Type
Citer ce document
Kraft, C. S., A. L. Hewlett, S. Koepsell, A. M. Winkler, C. J. Kratochvil, L. Larson, J. B. Varkey, A. K. Mehta, G. M. Lyon, 3rd, R. J. Friedman-Moraco, V. C. Marconi, C. E. Hill, J. N. Sullivan, D. W. Johnson, S. J. Lisco, M. J. Mulligan, T. M. Uyeki, A. K. McElroy, T. Sealy, S. Campbell, C. Spiropoulou, U. Stroher, I. Crozier, R. Sacra, M. J. Connor, Jr., V. Sueblinvong, H. A. Franch, P. W. Smith, B. S. Ribner, U. Nebraska Biocontainment and U. the Emory Serious Communicable Diseases (2015). "The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States." Clin Infect Dis 61(4): 496-502.
Résumé
BACKGROUND: The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. METHODS: We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. RESULTS: While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. CONCLUSIONS: It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
Accessibilité
free online - Pubmed Central
Was this resource helpful?