Marburg Virus Disease: a Summary for Clinicians

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Title

Marburg Virus Disease: a Summary for Clinicians

Subject

Description

This article is a summary of countermeasures for Marburg virus disease focusing on pathogenesis, clinical features, and diagnostics, with an emphasis on therapies and vaccines that have demonstrated potential for use in an emergency situation, through their evaluation in nonhuman primates (NHPs) and/or in humans.

Source

Kortepeter, M. G., K. Dierberg, E. S. Shenoy, and T. J. Cieslak.

Date Last Updated (Year-Month-Day)

2020-08-03

Citation

Kortepeter, M. G., K. Dierberg, E. S. Shenoy, and T. J. Cieslak. 2020. "Marburg Virus Disease: a Summary for Clinicians." International Journal of Infectious Disease. 99:233-42.

Abstract

Objectives: This article is a summary of countermeasures for Marburg virus disease focusing on pathogenesis, clinical features, and diagnostics, with an emphasis on therapies and vaccines that have demonstrated potential for use in an emergency situation, through their evaluation in nonhuman primates (NHPs) and/or in humans.

Methods: A standardized literature review was conducted on vaccines and treatments for each pathogen, with a focus on human and nonhuman primate data published in the last five years. More detail on the methods used are summarized in a companion methods paper.

Results: We identified six treatments and four vaccine platforms that have demonstrated potential benefit for treating or preventing infection in humans, through their efficacy in NHPs.

Conclusion: We provide succinct summaries of Marburg countermeasures to give the busy clinician a head start in reviewing the literature if faced with a patient with Marburg virus disease. We also provide links to other authoritative sources of information.

Keywords: Ebola virus; Marburg virus; antiviral countermeasure; antiviral therapy; filovirus; treatment; vaccine.

Accessibility

Free online, Elsevier Open Access and Pub Med Central.
https://doi.org/10.1016/j.ijid.2020.07.042
1201-9712/
2020 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/)