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Browse Items (1466 total)
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Creator: Scully, Marie, Deepak Singh, Robert Lown, Anthony Poles, Tom Solomon, Marcel Levi, David Goldblatt, Pavel Kotoucek, William Thomas, and William Lester.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-16
Description: The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a year, several vaccines have been developed and millions of doses delivered.… -
Creator: Chappell, Keith J., Francesca L. Mordant, Zheyi Li, Danushka K. Wijesundara, Paula Ellenberg, Julia A. Lackenby, Stacey T. M. Cheung, Naphak Modhiran, Michael S. Avumegah, Christina L. Henderson, Kym Hoger, Paul Griffin, Jillian Bennet, Luca Hensen,…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-19
Description: Given the scale of the ongoing COVID-19 pandemic, the development of vaccines based on different platforms is essential, particularly in light of emerging viral variants, the absence of information on vaccine-induced immune durability, and potential… -
Creator: Goepfert, Paul A., Bo Fu, Anne-Laure Chabanon, Matthew I. Bonaparte, Matthew G. Davis, Brandon J. Essink, Ian Frank, Owen Haney, Helene Janosczyk, Michael C. Keefer, Marguerite Koutsoukos, Murray A. Kimmel, Roger Masotti, Stephen J. Savarino, Lode…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-19
Description: CoV2 preS dTM is a stabilised pre-fusion spike protein vaccine produced in a baculovirus expression system being developed against SARS-CoV-2. We present interim safety and immunogenicity results of the first-in-human study of the CoV2 preS dTM… -
Creator: Hacisuleyman, Ezgi, Caryn Hale, Yuhki Saito, Nathalie E. Blachere, Marissa Bergh, Erin G. Conlon, Dennis J. Schaefer-Babajew, Justin DaSilva, Frauke Muecksch, Christian Gaebler, Richard Lifton, Michel C. Nussenzweig, Theodora Hatziioannou, Paul D.…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-21
Description: Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of clinical concern. In a cohort of 417 persons who had received the second dose of BNT162b2 (Pfizer–BioNTech) or mRNA-1273 (Moderna) vaccine at least 2 weeks… -
Creator: Greinacher, Andreas, Thomas Thiele, Theodore E. Warkentin, Karin Weisser, Paul A. Kyrle, and Sabine Eichinger.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-09
Description: Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1… -
Creator: Schultz, Nina H., Ingvild H. Sørvoll, Annika E. Michelsen, Ludvig A. Munthe, Fridtjof Lund-Johansen, Maria T. Ahlen, Markus Wiedmann, Anne-Hege Aamodt, Thor H. Skattør, Geir E. Tjønnfjord, and Pål A. Holme.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-09
Description: We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). -
Creator: the Siren Study Group
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-09
Description: Increased understanding of whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection is an urgent requirement. We aimed to investigate whether antibodies against SARS-CoV-2 were associated with a decreased… -
Creator: Frampton, Dan, Tommy Rampling, Aidan Cross, Heather Bailey, Judith Heaney, Matthew Byott, Rebecca Scott, Rebecca Sconza, Joseph Price, Marios Margaritis, Malin Bergstrom, Moira J. Spyer, Patricia B. Miralhes, Paul Grant, Stuart Kirk, Chris Valerio,…
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-12
Description: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of the B.1.1.7 variant of… -
Creator: the mRNA-1273 Study Group
Subject: Research
Item Type: Publication
Date Last Updated: 2021-04-06
Description: Interim results from a phase 3 trial of the Moderna mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine indicated 94% efficacy in preventing coronavirus disease 2019 (Covid-19). -
Creator: Schafer, Adam, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E. Ramirez, Norton P. Peet, Michael Caffrey, Gregory R. J. Thatcher, Erica Ollmann Saphire, Han Cheng, and Lijun Rong.
Subject: Research
Item Type: Publication
Date Last Updated: 2021-02-04
Description: Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that…