Pathophysiology of COVID-19
Elemento
Files for Download
NETEC_Pathophys_Final_102020.pdf
Item Type
GuíaTerms of Use
By accessing these materials you are agreeing to our terms of use, which may be found here: Terms of Use.
Visor de documentos
Título
Pathophysiology of COVID-19
Materia
Descripción
This printable flyer infographic tells you about the pathophysiology of COVID-19.
A typical presentation for COVID-19 includes cough, dyspnea, and an x-ray with diffuse opacities in the lungs. As the disease progresses, patients may develop increased respiratory failure, a hypercoagulable state, and excessive levels of pro-inflammatory and anti-inflammatory cytokines similar to Macrophage Activation Syndrome (MAS). We are learning more about what is typical every day, however.
Each of these hallmark physiological states of COVID-19 result from SARS-CoV-2 infection via binding of its spike protein to the Angiotensin Converting 2 (ACE2) receptor on a variety of cell types, primarily epithelial. ACE2 normally cleaves regulatory proteins including angiotensins-2. Binding of the virus disrupts normal cellular regulation resulting in high levels of inflammation and cell death.
A typical presentation for COVID-19 includes cough, dyspnea, and an x-ray with diffuse opacities in the lungs. As the disease progresses, patients may develop increased respiratory failure, a hypercoagulable state, and excessive levels of pro-inflammatory and anti-inflammatory cytokines similar to Macrophage Activation Syndrome (MAS). We are learning more about what is typical every day, however.
Each of these hallmark physiological states of COVID-19 result from SARS-CoV-2 infection via binding of its spike protein to the Angiotensin Converting 2 (ACE2) receptor on a variety of cell types, primarily epithelial. ACE2 normally cleaves regulatory proteins including angiotensins-2. Binding of the virus disrupts normal cellular regulation resulting in high levels of inflammation and cell death.
Autor
Fecha
2020-10-20
Was this resource helpful?