Browse Items (1476 total)

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  Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans

  Tags Ebola, Laboratory Testing, R-Res&Pub, Viral Hemorrhagic Fever, Virology
  Creator: McElroy, A. K., P. Shrivastava-Ranjan, J. R. Harmon, R. B. Martines, L. Silva-Flannery, T. D. Flietstra, C. S. Kraft, A. K. Mehta, G. M. Lyon, J. B. Varkey, B. S. Ribner, S. T. Nichol, S. R. Zaki, and C. F. Spiropoulou
  Subject: Research
  Item Type: Publication
  Date Last Updated: 2019-02
  Description: Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome…

• New filovirus disease classification and nomenclature.

  Tags Ebola, R-Res&Pub, Viral Hemorrhagic Fever, Virology
  Creator: Kuhn, J. H., T. Adachi, N. K. J. Adhikari, J. R. Arribas, I. E. Bah, D. G. Bausch, N. Bhadelia, M. Borchert, A. B. Brantsaeter, D. M. Brett-Major, T. H. Burgess, D. S. Chertow, C. G. Chute, T. J. Cieslak, R. Colebunders, I. Crozier, R. T. Davey, H.…
  Subject: Research
  Item Type: Publication
  Date Last Updated: 2019-05
  Description: The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a…

• Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination.

  Tags Antibodies, Ebola, Immunology, R-Res&Pub, Vaccine Study, Virology
  Creator: Ellebedy, A. H., K. J. Jackson, H. T. Kissick, H. I. Nakaya, C. W. Davis, K. M. Roskin, A. K. McElroy, C. M. Oshansky, R. Elbein, S. Thomas, G. M. Lyon, C. F. Spiropoulou, A. K. Mehta, P. G. Thomas, S. D. Boyd, and R. Ahmed
  Subject: Research
  Item Type: Publication
  Date Last Updated: 2016-10
  Description: Antigen-specific B cells bifurcate into antibody-secreting cells (ASCs) and memory B cells (MBCs) after infection or vaccination.

• Essentials of filoviral load quantification.

  Tags Ebola, Outbreaks, R-Res&Pub, Viral Hemorrhagic Fever, Virology
  Creator: Cnops, L., J. van Griensven, A. N. Honko, D. G. Bausch, A. Sprecher, C. E. Hill, R. Colebunders, J. C. Johnson, A. Griffiths, G. F. Palacios, C. S. Kraft, G. Kobinger, A. Hewlett, D. A. Norwood, P. Sabeti, P. B. Jahrling, P. Formenty, J. H. Kuhn, and…
  Subject: Research
  Item Type: Publication
  Date Last Updated: 2016-07
  Description: Quantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and infectivity. Copyright © 2016 Elsevier Ltd. All rights reserved.

• Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection

  Tags Ebola, Immunology, Outbreaks, R-Res&Pub, Research, Vaccine Study
  Creator: Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albariño CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD,…
  Subject: Research
  Item Type: Publication
  Date Last Updated: 2019-05-30
  Description: Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak.
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  Upholding Family-Centered Care in the Face of High-Consequence Pathogens--Thinking Inside the Room--Reply

  Tags Contact Transmission, Droplet Transmission, Infection Prevention and Control, Pediatrics, R-Res&Pub, R-SP, Treatment and Care
  Creator: Mehrotra, Preeti, Andi L. Shane, and Aaron M. Milstone.
  Subject: Research
  Item Type: Publication
  Date Last Updated: 2016-03
  Description: In Reply We appreciate the response by Curley and Meyer to our Viewpoint titled “Family-Centered Care and High-Consequence Pathogens: Thinking Outside the Room”1 and the continued dialogue regarding family-centered care and high-consequence…
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  Development of a Pediatric Ebola Predictive Score, Sierra Leone

  Tags Diagnosis, Ebola, Epidemiology, Outbreaks, Pediatrics, R-Res&Pub, R-SP, Viral Hemorrhagic Fever
  Creator: Fitzgerald F, Wing K, Naveed A, Gbessay M, Ross JCG, Checchi F, Youkee D, Jalloh MB, Baion DE, Mustapha A, Jah H, Lako S, Oza S, Boufkhed S, Feury R, Bielicki J, Williamson E, Gibb DM, Klein N, Sahr F, Yeung S.
  Subject: Research
  Item Type: Publication
  Date Last Updated: 2018-02
  Description: We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score.

• Corporate Report: Secure Specimen Transfer from Ebola Biobank to the UK (United Kingdom)

  Tags Ebola, R-Res&Pub, Specimen Transport, Therapeutics, Vaccine Study
  Creator: United Kingdom Department of Health (DH)
  Subject: Research
  Item Type: Guide
  Date Last Updated: 2019-07-19
  Description: This report summarizes the establishment of the Ebola Biobank, its governance, and how materials were safely transported in 2015 from West Africa to the United Kingdom for curation by Public Health England. The Biobank is a secure but accessible…

• Cardiac MRI Findings Suggest Myocarditis in Severe Ebola Virus Disease

  Tags R-Res&Pub
  Creator: Chertow DS, Childs RW, Arai AE, Davey RT Jr.
  Subject: Research
  Item Type: Publication
  Date Last Updated: 2017-06-05
  Description: In March, 2015, a 34 year-old previously healthy male healthcare worker was evacuated from Sierra Leone to the National Institutes of Health (NIH) Clinical Research Center for the management of severe Ebola virus disease (EVD).

• Independent monitoring board recommends early termination of Ebola therapeutics trial in DRC because of favorable results with two of four candidates

  Tags Ebola, R-Res&Pub, Therapeutics
  Creator: NIH
  Subject: Research
  Item Type: Hyperlink
  Date Last Updated: 2019-08-12
  Description: The Pamoja Tulinde Maisha (PALM [together save lives]) study is a randomized, controlled trial of four investigational agents (ZMapp, remdesivir, mAb114 and REGN-EB3) for the treatment of patients with Ebola virus disease. The study began on Nov. 20,…