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Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host


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Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host


A 45-year-old man with severe antiphospholipid syndrome complicated by diffuse alveolar hemorrhage, who was receiving anticoagulation therapy, glucocorticoids, cyclophosphamide, and intermittent rituximab and eculizumab, was admitted to the hospital with fever.




Choi, Bina, Manish C. Choudhary, James Regan, Jeffrey A. Sparks, Robert F. Padera, Xueting Qiu, Isaac H. Solomon, Hsiao-Hsuan Kuo, Julie Boucau, Kathryn Bowman, U. Das Adhikari, Marisa L. Winkler, Alisa A. Mueller, Tiffany Y. T. Hsu, Michaël Desjardins, Lindsey R. Baden, Brian T. Chan, Bruce D. Walker, Mathias Lichterfeld, Manfred Brigl, Douglas S. Kwon, Sanjat Kanjilal, Eugene T. Richardson, A. Helena Jonsson, Galit Alter, Amy K. Barczak, William P. Hanage, Xu G. Yu, Gaurav D. Gaiha, Michael S. Seaman, Manuela Cernadas, and Jonathan Z. Li. 2020. "Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host." New England Journal of Medicine.


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