In the wake of caring for four patients with active Ebola virus in 2014, Emory clinicians have taken stock of lessons learned in infectious disease prevention, therapeutic care, and health aftereffects and are sharing that information broadly with other health care professionals and first responders.
The 2013-2016 West African Ebola virus disease (EVD) outbreak has been the largest in history with 28,616 cases and 11,310 deaths in the highest transmission countries of Sierra Leone, Guinea, and Liberia.
Shantha, J. G., I. Crozier, J. B. Varkey, C. S. Kraft, G. M. Lyon, 3rd, A. K. Mehta, R. D. Carlson, C. E. Hill, G. Kumar, M. R. Debiec, P. S. Patel, T. W. Olsen, R. B. Nussenblatt, D. F. Martin, U. Stroher, T. M. Uyeki, B. S. Ribner, J. R. Smith and S. Yeh (2016). "Long-term Management of Panuveitis and Iris Heterochromia in an Ebola Survivor." Ophthalmology 123(12): 2626-2628 e2622.
Abstract
The 2013-2016 West African Ebola virus disease (EVD) outbreak has been the largest in history with 28,616 cases and 11,310 deaths in the highest transmission countries of Sierra Leone, Guinea, and Liberia. Reports of uveitis have emerged in EVD survivors. Herein we discuss clinical features, multimodality imaging, and long-term management of aggressive, sight-threatening panuveitis, in an EVD survivor, providing insight into the pathogenesis of this condition.
Uyeki, T. M., B. R. Erickson, S. Brown, A. K. McElroy, D. Cannon, A. Gibbons, T. Sealy, M. H. Kainulainen, A. J. Schuh, C. S. Kraft, A. K. Mehta, G. M. Lyon, 3rd, J. B. Varkey, B. S. Ribner, R. T. Ellison, 3rd, E. Carmody, G. J. Nau, C. Spiropoulou, S. T. Nichol and U. Stroher (2016). "Ebola Virus Persistence in Semen of Male Survivors." Clin Infect Dis 62(12): 1552-1555.
Abstract
We investigated the duration of Ebola virus (EBOV) RNA and infectious EBOV in semen specimens of 5 Ebola virus disease (EVD) survivors. EBOV RNA and infectious EBOV was detected by real-time RT-PCR and virus culture out to 290 days and 70 days, respectively, after EVD onset.
Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown.
This article was corrected in volume 372 on page 2469.
Varkey, J. B., J. G. Shantha, I. Crozier, C. S. Kraft, G. M. Lyon, A. K. Mehta, G. Kumar, J. R. Smith, M. H. Kainulainen, S. Whitmer, U. Stroher, T. M. Uyeki, B. S. Ribner and S. Yeh (2015). "Persistence of Ebola Virus in Ocular Fluid during Convalescence." N Engl J Med 372(25): 2423-2427.
Abstract
Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.