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Laboratory Resources:
Highly Pathogenic Avian Influenza (HPAI)
ABOUT HPAI:
Avian influenza is a disease in birds caused by infection with avian (bird) influenza (flu) Type A viruses. Highly
pathogenic avian influenza viruses cause severe disease and high mortality in infected poultry. Illness in humans
from bird flu virus infections has ranged in severity from no symptoms or mild illness to severe disease that resulted
in death. Asian lineage H7N9 and highly pathogenic avian influenza Asian lineage H5N1 viruses have been
responsible for the most human illness from bird flu viruses worldwide to date.
CDC Information on Avian Influenza in Birds
CLICK HERE
DIAGNOSTIC TESTING:
Rapid influenza tests may detect HPAI but will not distinguish between seasonal influenza and HPAI. Patients with
influenza-like illness and avian exposure history should be considered for HPAI testing. Respiratory panels that
distinguish influenza subtypes may detect HPAI but will give an “unsubtypeable” result.
Some public health laboratories have the capability of detecting highly pathogenic avian influenzas from the H5 and
H7 lineages*. Check with your public health laboratory on their capabilities. Submission to CDC reference
laboratories for further characterization should be coordinated through your state or local public health laboratory.
*Currently, Avian exposure is a prerequisite for testing
CDC Page Interim Guidance for Testing and Specimen Collection
CLICK HERE
CDC Page on State Health Department Directory
CLICK HERE
SPECIMEN TYPE:
Various respiratory specimens may be acceptable; check with your local public health laboratories on their
specimen requirements. Swabs must be in viral transport media or another acceptable media that has been
designated by your public health laboratory. Swab specimens should be collected using only swabs with a
synthetic tip, such as nylon or Dacron ®, and an aluminum or plastic shaft. Calcium alginate swabs are
unacceptable, and cotton swabs with wooden shafts are not recommended because they can cause a
false-negative result.
NETEC Video on Specimen Collection Using NP Swabs
CLICK HERE
NETEC Specimen Collection Tips for the Health Care Professional
CLICK HERE
PACKAGING AND SHIPPING:
Clinical specimens are considered a UN3373, Biological Substance, Category B (IATA Division 6.2 Infectious Substances).
Important: Check regulations often as designations can change for new and/or emerging pathogens.
APHL Category B Packaging & Shipping Guide PDF
CLICK HERE
Viral cultures are discouraged and are considered a Category A, Dangerous Goods.
Training on Packaging & Shipping Dangerous Goods
CLICK HERE
MANAGING AND TESTING ROUTINE CLINICAL SPECIMENS:
Most clinical specimens for clinical care may be managed as routine specimens in your facility’s core laboratory
using standard safety precautions and PPE. Respiratory specimens should be handled with enhanced precautions
and PPE based on your facility’s risk assessment. Additionally, aerosol-generating procedures should be avoided
with respiratory specimens.
3.1.2023
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Title
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Develop
Description
An account of the resource
<h2><span>These files will help you <strong><em>develop</em></strong> your program and plans based on what you have discovered.</span></h2>
<p style="font-size:120%;">Find model protocols and procedures and more in-depth training resources. You can go to the <a href="/exhibits/show/leadership"><button>Leadership Toolbox</button></a> or the <a href="https://repository.netecweb.org/exhibits/show/specialpopulations"><button>Special Populations</button></a> section. You can also go to the <a href="https://repository.netecweb.org/exhibits/show/netec-education/justintime"><button> Just in Time Training</button></a> page, the <a href="https://repository.netecweb.org/exhibits/show/ppe101/ppe"><button> PPE</button></a> page, or the <a href="https://repository.netecweb.org/exhibits/show/ems/prehospital"><button>EMS</button></a> page. <span>Subscribe to the NETEC <a href="https://www.youtube.com/channel/UCDpHc1LkcEpiWR0q7ll5eZQ" target="_blank" rel="noreferrer noopener"><button>Youtube Channel</button></a> to get all new Skills videos!</span></p>
Guide
Document providing operation or response information, general guidance documents.
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Title
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Laboratory Resources: Highly Pathogenic Avian Influenza (HPAI)
Subject
The topic of the resource
Laboratory
Description
An account of the resource
This guide, printable flyer, provides laboratory resources related to Highly Pathogenic Avian Influenza (HPAI). This is a part of a series of one-page resource guides for laboratorians.
Creator
An entity primarily responsible for making the resource
NETEC
Date
A point or period of time associated with an event in the lifecycle of the resource
2023-03-02
Coverage
The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant
2025-05-17
Contributor
An entity responsible for making contributions to the resource
2022-09-27 - general asset review - Treatment & Care group
2023-03-02 - updated by Laboratory group
Avian Influenza
Flu
Highly Pathogenic Avian Influenza (HPAI)
Influenza
Lab
Laboratorian
Laboratory
Laboratory Testing
One Page Flyer
One-pager
R-Lab
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https://repository.netecweb.org/files/original/42cc1379f3523ef4c23835c9b4049a9b.png
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Title
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Discover
Description
An account of the resource
<div style="background-color:#c7e5f8;">
<h2 style="background-color:#c7e5f8;"><span style="font-size:80%;line-height:24px;"><a href="https://repository.netecweb.org/exhibits/show/ncov/ncov"><button>COVID-19 Update</button></a><a href="https://repository.netecweb.org/news#Map"><button>Outbreak Map</button></a><a href="https://repository.netecweb.org/news#News"><button>Newsfeed</button></a><a href="https://repository.netecweb.org/exhibits/show/monkeypox/monkeypox"><button>Monkeypox 2021</button></a><a href="https://repository.netecweb.org/exhibits/show/drcebola2018/drcebola2018"><button>2020 Ebola Update</button></a><a href="https://repository.netecweb.org/ebolatimeline"><button>Ebola Timeline</button></a><a href="https://repository.netecweb.org/exhibits/show/mers/mers"><button>MERS</button></a><a href="https://repository.netecweb.org/exhibits/show/aerosol/aerosol"><button>Airborne Transmission</button></a></span></h2>
<h2 style="background-color:#c7e5f8;">Discover Background Data and Resources:</h2>
<ul><li>
<p><span style="line-height:24px;">Get introduced to NETEC through the interactive timeline of special pathogens below.* This timeline describes some significant special pathogen events in recent history.</span></p>
</li>
<li>
<p><span style="line-height:24px;">Find out more about the 2014 Ebola outbreak and the development of the ASPR/CDC-supported network of healthcare facilities preparing for the next outbreak through <em><a href="/ebolatimeline"><button>the Ebola timeline</button></a>.</em></span></p>
</li>
</ul><ul><li>
<p><span style="line-height:24px;">This NETEC Repository helps to provide training and educational resources to prepare for future special pathogen events. </span></p>
</li>
</ul><ul><li>
<p><span style="line-height:24px;">Explore the files BELOW THE TIMELINE to <em><strong>discover and learn</strong></em> more about Ebola and other Special Pathogens, an overview of special pathogens, clinically managing patients affected, and readying healthcare teams and systems to keep everyone safe.</span></p>
</li>
</ul><h2 style="background-color:#c7e5f8;">Timeline of Special Pathogens:</h2>
<a href="#click">Skip timeline</a>
<p style="margin-bottom:0;"><iframe width="100%" height="635" style="border:1px solid #000000;" src="https://cdn.knightlab.com/libs/timeline3/latest/embed/index.html?source=1AQiHJEzkhEi71uIi7wTWWgSFRwR6wRbRyfhbASrw3Ig&font=Default&lang=en&initial_zoom=2&height=650" title="Timeline of Special Pathogens"></iframe></p>
<h2 style="background-color:#c7e5f8;"><span style="font-size:70%;">*Click for <a href="/timeline2access"><button>a screen reader accessible table of this timeline</button></a>. </span></h2>
</div>
Webinar
Portal access to a webinar
URL
https://emergency.cdc.gov/coca/calls/2017/callinfo_110217.asp
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Ecology of Emerging Zoonotic Diseases
Subject
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General
Description
An account of the resource
This webinar discusses Nipah virus and Ebola in terms of how human activity increases contact with wildlife and thus zoonotic disease emergence, and discusses interventions that reduce such risk.
Creator
An entity primarily responsible for making the resource
CDC, Office of Public Health Preparedness and Response (CDC OPHPR)
Date
A point or period of time associated with an event in the lifecycle of the resource
2017-11-02
Contributor
An entity responsible for making contributions to the resource
2022-03-17 by Anna Yaffee (Adult Care Group) keep in Resource Library
2023-02-19 by Anna Yaffee T&C group Q1 review
Coverage
The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant
2026-02-19
Avian Influenza
Coronavirus
Crimean Congo Haemorrhagic Fever (CCHF)
Ebola
Epidemic
Lassa
Marburg
Nipah (NiV)
Outbreaks
Pandemic
Public Health
R-Gen
Respiratory Pathogen
SARS
Special Pathogens
Viral Hemorrhagic Fever
Zoonotic